Binding affinities and activation of Asp712Ala and Cys100Ser mutated kinin B1 receptor forms suggest a bimodal scheme for the molecule of bound-DABK

Mutant forms of kinin B1 receptor (B1R) and analogs of the full agonist des-Arg9-bradykinin (DABK) were investigated aiming to verify the importance of selected receptor residues and of each agonist-peptide residue in the specific binding and activation. Linked by a specific disulfide bond (Cys100–C...

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Veröffentlicht in:	Regulatory peptides 2013-02, Vol.181, p.37-44
Hauptverfasser:	Rodrigues, E.S., Martin, R.P., Silva, R.F., Nakaie, C.R., Oliveira, L., Shimuta, S.I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Amino Acid Sequence Angiotensin II type I receptor Animals Binding Sites DesArg9BK Kinin B1 receptor Mice Mice, Inbred C57BL Models, Molecular Molecular Sequence Data Mutation Peptides - chemistry Peptides - genetics Peptides - pharmacology Protein Binding Protein Structure, Secondary Receptor, Bradykinin B1 - agonists Receptor, Bradykinin B1 - genetics Receptor, Bradykinin B1 - metabolism Sequence Alignment Stomach - drug effects Stomach - metabolism Structure-Activity Relationship Tissue Culture Techniques
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