Inhibition of protein glycation by urea and thiourea derivatives of glycine/proline conjugated benzisoxazole analogue – Synthesis and structure–activity studies

Inhibition of protein glycation by urea and thiourea derivatives of glycine/proline conjugated benzisoxazole analogue – Synthesis and structure–activity studies

Synthesis of a new series of urea/thiourea derivatives of Gly/Pro conjugated benzisoxazole has been reported. Structure of the compounds was characterized by physical and spectroscopical data and has been screened for their in vitro antiglycation activity. Several compounds showed promising activity...

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Veröffentlicht in:European journal of medicinal chemistry 2013-02, Vol.60, p.325-332
Hauptverfasser: Shantharam, C.S., Suyoga Vardhan, D.M., Suhas, R., Sridhara, M.B., Gowda, D. Channe
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Animals
Antiglycation
Cattle
Conjugation
Dose-Response Relationship, Drug
Glycine - chemistry
Isoxazoles - chemistry
Molecular Structure
Proline - chemistry
Serum Albumin, Bovine - antagonists & inhibitors
Serum Albumin, Bovine - metabolism
Structure-Activity Relationship
Urea - analogs & derivatives
Urea - chemistry
Urea - pharmacology
Urea/thiourea
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Zusammenfassung:Synthesis of a new series of urea/thiourea derivatives of Gly/Pro conjugated benzisoxazole has been reported. Structure of the compounds was characterized by physical and spectroscopical data and has been screened for their in vitro antiglycation activity. Several compounds showed promising activity with IC50 
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2012.12.029