A Population-Specific Uncommon Variant in GRIN3A Associated with Schizophrenia

Background Genome-wide association studies have successfully identified several common variants showing robust association with schizophrenia. However, individually, these variants only produce a weak effect. To identify genetic variants with larger effect sizes, increasing attention is now being pa...

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Veröffentlicht in:	Biological psychiatry (1969) 2013-03, Vol.73 (6), p.532-539
Hauptverfasser:	Takata, Atsushi, Iwayama, Yoshimi, Fukuo, Yasuhisa, Ikeda, Masashi, Okochi, Tomo, Maekawa, Motoko, Toyota, Tomoko, Yamada, Kazuo, Hattori, Eiji, Ohnishi, Tetsuo, Toyoshima, Manabu, Ujike, Hiroshi, Inada, Toshiya, Kunugi, Hiroshi, Ozaki, Norio, Nanko, Shinichiro, Nakamura, Kazuhiko, Mori, Norio, Kanba, Shigenobu, Iwata, Nakao, Kato, Tadafumi, Yoshikawa, Takeo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Asian Continental Ancestry Group - genetics Asian Continental Ancestry Group - psychology Biological and medical sciences Bipolar disorder Bipolar Disorder - genetics Bipolar disorders Case-Control Studies CFB DNMT1 FAAH Female Genetic Association Studies Genetic Predisposition to Disease - genetics Genotype GRIN3A Humans Male Medical sciences Middle Aged Mood disorders MYO18B NR3A Polymorphism, Single Nucleotide - genetics Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses rare variants Receptors, N-Methyl-D-Aspartate - genetics Schizophrenia Schizophrenia - genetics
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Zusammenfassung:	Background Genome-wide association studies have successfully identified several common variants showing robust association with schizophrenia. However, individually, these variants only produce a weak effect. To identify genetic variants with larger effect sizes, increasing attention is now being paid to uncommon and rare variants. Methods From the 1000 Genomes Project data, we selected 47 candidate single nucleotide variants (SNVs), which were: 1) uncommon (minor allele frequency
ISSN:	0006-3223 1873-2402
DOI:	10.1016/j.biopsych.2012.10.024