Jatropholane-Type Diterpenes from Euphorbia sikkimensis

Four new jatropholane-type diterpenes (1–4), named sikkimenoids A–D, were isolated from the aerial parts of Euphorbia sikkimensis. The structural elucidations of 1–4 were accomplished by extensive NMR analyses, and their absolute configurations were established by ECD calculations. Compound 2 exhibi...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2013-02, Vol.76 (2), p.265-269
Hauptverfasser:	Yang, Da-Song, Zhang, You-Li, Peng, Wei-Bing, Wang, Li-Yan, Li, Zi-Lei, Wang, Xue, Liu, Ke-Chun, Yang, Yong-Ping, Li, Hong-Lin, Li, Xiao-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - isolation & purification Angiogenesis Inhibitors - pharmacology Animals Disease Models, Animal Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Drug Screening Assays, Antitumor Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology Euphorbia - chemistry Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Zebrafish
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Zusammenfassung:	Four new jatropholane-type diterpenes (1–4), named sikkimenoids A–D, were isolated from the aerial parts of Euphorbia sikkimensis. The structural elucidations of 1–4 were accomplished by extensive NMR analyses, and their absolute configurations were established by ECD calculations. Compound 2 exhibited weak antiangiogenic activity with an IC50 value of 43.0 μM when evaluated using a zebrafish model.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np300799n