Reduced insulin secretion and glucose intolerance are involved in the fasting susceptibility of common vampire bats

Highlights ► Reduced insulinemia and insulin secretion impairment in Desmodus rotundus . ► Irregular and small pancreatic islets, with reduced β-cell mass, showed through morphometrical analyses. ► Glucose-stimulated insulin secretion impairment, although preserved leucine response. ► Inability to h...

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Veröffentlicht in:	General and comparative endocrinology 2013-03, Vol.183, p.1-6
Hauptverfasser:	Freitas, Mariella B, Queiroz, Joicy F, Dias Gomes, Carolinne I, Collares-Buzato, Carla B, Barbosa, Helena C, Boschero, Antonio C, Gonçalves, Carlos A, Pinheiro, Eliana C
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acids Animals blood serum Chiroptera Chiroptera - metabolism Desmodus Desmodus rotundus diet Endocrinology & Metabolism energy Fasting Female glucose Glucose - metabolism Glucose Intolerance - metabolism Glucose Intolerance - veterinary Glucose Tolerance Test - veterinary glucose tolerance tests hyperinsulinemia Immunocytochemistry Immunohistochemistry Insulin Insulin - blood Insulin - metabolism Insulin Secretion islets of Langerhans Islets of Langerhans - metabolism Islets of Langerhans - pathology Male mammals morphometry Pancreatic islets Protein
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Zusammenfassung:	Highlights ► Reduced insulinemia and insulin secretion impairment in Desmodus rotundus . ► Irregular and small pancreatic islets, with reduced β-cell mass, showed through morphometrical analyses. ► Glucose-stimulated insulin secretion impairment, although preserved leucine response. ► Inability to handle glucose overload by vampire bats, indicating glucose intolerance.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2012.11.023