The anti-inflammatory effect of alloferon on UVB-induced skin inflammation through the down-regulation of pro-inflammatory cytokines

Highlights ► Alloferon suppressed pro-inflammatory cytokines production in keratinocyte, HaCat. ► Alloferon suppressed IL-6 production via the down-regulation of phosphorylation of p38 MAPK in keratinocyte, HaCat. ► The topical treatment with alloferon on hairless mice skin after chronic UVB irradia...

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Veröffentlicht in:	Immunology letters 2013-01, Vol.149 (1), p.110-118
Hauptverfasser:	Kim, Yejin, Lee, Seung Koo, Bae, Seyeon, Kim, Hyemin, Park, Yunseong, Chu, Nag Kyun, Kim, Stephanie G, Kim, Hang-Rae, Hwang, Young-il, Kang, Jae Seung, Lee, Wang Jae
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Alloferon Animals Antineoplastic Agents - pharmacology Antiviral Agents - pharmacology Calliphora vicina Cell Line Cytokines - biosynthesis Cytokines - immunology Dermatitis - drug therapy Dermatitis - immunology Dermatitis - metabolism Dermatitis - pathology Down-Regulation - drug effects Down-Regulation - immunology Down-Regulation - radiation effects Humans Inflammation Inflammation Mediators - immunology Inflammation Mediators - metabolism Interleukin-6 MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - immunology MAP Kinase Signaling System - radiation effects p38 mitogen-activated protein kinase Peptides - pharmacology RNA, Messenger - biosynthesis RNA, Messenger - immunology Skin - immunology Skin - metabolism Skin - pathology Ultraviolet B radiation Ultraviolet Rays - adverse effects
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Beschreibung
Zusammenfassung:	Highlights ► Alloferon suppressed pro-inflammatory cytokines production in keratinocyte, HaCat. ► Alloferon suppressed IL-6 production via the down-regulation of phosphorylation of p38 MAPK in keratinocyte, HaCat. ► The topical treatment with alloferon on hairless mice skin after chronic UVB irradiation showed the decrease of epithelial thickness and the inhibition of IL-6 production.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2012.09.005