In vitro assessment of mesenchymal stem cells immunosuppressive potential in multiple sclerosis patients

Highlights ► MSC inhibit mitogen/myelin-stimulated memory T cells proliferation in MS patients. ► MSC suppression of myelin-induced T cell proliferation correlates with EDSS score. ► Index of MSC Suppression reflects the intensity of MSC immunosuppressive potential. ► MSC can limit T cells response...

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Veröffentlicht in:	Immunology letters 2013-01, Vol.149 (1), p.9-18
Hauptverfasser:	Zafranskaya, Marina M, Nizheharodova, Darya B, Yurkevich, Mariya Yu, Lamouskaya, Natallia V, Motuzova, Yana M, Bagatka, Svetlana S, Ivanchik, Halina I, Fedulov, Alexander S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Cell Proliferation Cells, Cultured Female Gene Expression Regulation - immunology Humans Immune Tolerance Immunosuppression Interferon gamma Receptor Male Mesenchymal stem cells Mesenchymal Stem Cells - immunology Mesenchymal Stem Cells - pathology Middle Aged Multiple sclerosis Multiple Sclerosis - immunology Multiple Sclerosis - pathology Receptors, Interferon - immunology T-Lymphocytes - immunology T-Lymphocytes - pathology
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Zusammenfassung:	Highlights ► MSC inhibit mitogen/myelin-stimulated memory T cells proliferation in MS patients. ► MSC suppression of myelin-induced T cell proliferation correlates with EDSS score. ► Index of MSC Suppression reflects the intensity of MSC immunosuppressive potential. ► MSC can limit T cells response in MS patients via IFN-γ-IDO-mediated mechanism. ► CD119 expression in activated T cells increased in the presence of MSC.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2012.10.010