A Mouse Following in the Footsteps of Human Prehistory

A Mouse Following in the Footsteps of Human Prehistory

One of the strongest signals of positive selection in humans surrounds the V370A variant of Ectodysplasin A receptor (EDAR). However, its phenotypic consequences and impetus for selection are not well understood. Kamberov et al. nail down when it originated and, using transgenic mice, delineate its...

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Veröffentlicht in:Cell 2013-02, Vol.152 (4), p.667-668
Hauptverfasser: Vohr, Samuel H., Green, Richard E.
Format: Artikel
Sprache:eng
Schlagworte:
humans
mice
selection
transgenic animals
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Beschreibung
Zusammenfassung:One of the strongest signals of positive selection in humans surrounds the V370A variant of Ectodysplasin A receptor (EDAR). However, its phenotypic consequences and impetus for selection are not well understood. Kamberov et al. nail down when it originated and, using transgenic mice, delineate its phenotypic impacts.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2013.01.039