Changing course by lymphocyte lineage redirection

The fate of T cells differentiating into the CD4 or CD8 lineage is typically fixed when cells leave the thymus. However, CD4 + helper T cells can be reprogrammed to develop into CD4 + CD8α + cytotoxic T lymphocytes in the gut.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2013-03, Vol.14 (3), p.199-201
1. Verfasser:	Anderson, Michele K
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136 631/250/1619/554 631/250/1619/554/1898 631/250/2502 631/250/347 Animals Biomedicine Immunology Infectious Diseases Lymphocytes news-and-views T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Helper-Inducer - immunology Transcription Factors - genetics Transcription Factors - metabolism
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Beschreibung
Zusammenfassung:	The fate of T cells differentiating into the CD4 or CD8 lineage is typically fixed when cells leave the thymus. However, CD4 + helper T cells can be reprogrammed to develop into CD4 + CD8α + cytotoxic T lymphocytes in the gut.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/ni.2544