Environmental oestrogens and breast cancer: long-term low-dose effects of mixtures of various chemical combinations

The incidence of breast cancer has risen worldwide to unprecedented levels in recent decades, making it now the major cancer of women in many parts of the world. 1 Although diet, alcohol, radiation and inherited loss of BRCA1/2 genes have all been associated with increased incidence, the main identified risk factors are life exposure to hormones including physiological variations associated with puberty/pregnancy/menopause, 1 personal choice of use of hormonal contraceptives 2 and/or hormone replacement therapy. 3-6 On this basis, exposure of the human breast to the many environmental pollutant chemicals capable of mimicking or interfering with oestrogen action 7 should also be of concern. 8 Hundreds of such environmental chemicals have now been measured in human breast tissue from a range of dietary and domestic exposure sources 7 9 including persistent organochlorine pollutants (POPs), 10 polybrominated diphenylethers and polybromobiphenyls, 11 polychlorinated biphenyls, 12 dioxins, 13 alkyl phenols, 14 bisphenol-A and chlorinated derivatives, 15 as well as other less lipophilic compounds such as parabens (alkyl esters of p-hydroxybenzoic acid), 16 but studies investigating any association between raised levels of such compounds and the development of breast cancer remain inconclusive. 7-16 However, the functionality of these chemicals has continued to be assessed on the basis of individual chemicals rather than the environmental reality of long-term low-dose exposure to complex mixtures.