Early antidote use associated with noninvasive ventilation in prehospital treatment of methadone intoxication

[...]in methadone intoxications presenting central nervous depression and respiratory distress, the early use of an opioid antagonist and NIV may allow to avoid the use of systematic endotracheal intubation and its potential complications. [...]in case of severe methadone intoxications associated with neurologic depression and acute distress respiratory syndrome, the early use of an opioid antagonist and NIV may allow to avoid a systematical endotracheal intubation and its potential morbidity.