Hypochlorous Acid Turn-on Fluorescent Probe Based on Oxidation of Diphenyl Selenide

A BODIPY-based fluorescent probe, HCSe, has been successfully developed for the rapid detection of hypochlorous acid based on the specific HOCl-promoted oxidation of diphenyl selenide in response to the amount of HOCl. Confocal fluorescence microscopy imaging using RAW264.7 cells showed that the new...

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Veröffentlicht in:	Organic letters 2013-02, Vol.15 (4), p.878-881
Hauptverfasser:	Liu, Shi-Rong, Wu, Shu-Pao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biphenyl Compounds - chemistry Boron Compounds - chemical synthesis Boron Compounds - chemistry Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Hypochlorous Acid - analysis Hypochlorous Acid - chemistry Macrophages - drug effects Mice Molecular Structure Organoselenium Compounds - chemical synthesis Organoselenium Compounds - chemistry Oxidation-Reduction
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Zusammenfassung:	A BODIPY-based fluorescent probe, HCSe, has been successfully developed for the rapid detection of hypochlorous acid based on the specific HOCl-promoted oxidation of diphenyl selenide in response to the amount of HOCl. Confocal fluorescence microscopy imaging using RAW264.7 cells showed that the new probe HCSe could be used as an effective fluorescent probe for detecting HOCl in living cells.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol400011u