Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b]pyridines as soluble guanylate cyclase stimulators

Novel guanylate cyclase stimulators are disclosed. Design, synthesis, SAR, and pharmacological profile of the compounds are discussed.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2013-03, Vol.23 (5), p.1197-1200
Hauptverfasser:	Griebenow, Nils, Schirok, Hartmut, Mittendorf, Joachim, Straub, Alexander, Follmann, Markus, Stasch, Johannes-Peter, Knorr, Andreas, Schlemmer, Karl-Heinz, Redlich, Gorden
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidic heterocycles Animals Carboxylic acid isosteres chemistry Guanylate cyclase Guanylate Cyclase - chemistry Guanylate Cyclase - metabolism Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology pyridines Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Rats SAR Stimulation, Chemical Stimulator Structure-Activity Relationship
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Novel guanylate cyclase stimulators are disclosed. Design, synthesis, SAR, and pharmacological profile of the compounds are discussed.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2013.01.028