Efficacy of Ivermectin Versus Dual Infections of Haemonchus contortus and Heligmosomoides polygyrus in the Mouse
This report describes a novel assay for the detection of gastrointestinal anthelmintics using mice infected with Haemonchus contortus and adapted to the 1 animal/test group protocol. Mice infected with both H. contortus and Heligmosomoides polygyrus were fed ivermectin-medicated diets for 6 days. A...
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Veröffentlicht in: | The Journal of parasitology 2013-02, Vol.99 (1), p.168-169 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | This report describes a novel assay for the detection of gastrointestinal anthelmintics using mice infected with Haemonchus contortus and adapted to the 1 animal/test group protocol. Mice infected with both H. contortus and Heligmosomoides polygyrus were fed ivermectin-medicated diets for 6 days. A dietary level of 0.09375 ppm was 98.1% effective against the 0- to 6-day-old abomasal stomach worm of sheep, whereas a level of 0.75 ppm reduced the 3- to 9-day-old H. polygyrus worm burden by 94.0%. H. contortus was approximately 8-fold more sensitive to ivermectin than was H. polygyrus in this model. The sensitivity of this assay rivals that of the gerbil-Trichostrongylus colubriformis model while utilizing a more economical host. |
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ISSN: | 0022-3395 1937-2345 |
DOI: | 10.1645/12-22.1 |