Anti-diabetic activities of Gegen Qinlian Decoction in high-fat diet combined with streptozotocin-induced diabetic rats and in 3T3-L1 adipocytes

Gegen Qinlian Decoction (GGQLD) is one of the well-known traditional Chinese medicines. Recently, it was reported that GGQLD had good clinical effects on type 2 diabetes mellitus. However, few studies have confirmed in detail the anti-diabetic activities of GGQLD in vivo and in vitro. In the present...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2013-02, Vol.20 (3-4), p.221-229
Hauptverfasser:	Zhang, Chang-Hua, Xu, Guo-Liang, Liu, Yu-Hui, Rao, Yi, Yu, Ri-Yue, Zhang, Zhong-Wei, Wang, Yue-Sheng, Tao, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes - drug effects Adipocytes - metabolism Adiponectin - metabolism Animals Anti-diabetic activities Azo Compounds Body Weight - drug effects Care and treatment Chromatography, High Pressure Liquid Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - etiology Diabetic rats Diet, High-Fat - adverse effects Drug Evaluation, Preclinical Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Gegen Qinlian Decoction Gene Expression - drug effects Glucose - metabolism Health aspects Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Ketogenic diet Male Medicine, Chinese Mice Phytotherapy Rats Rats, Sprague-Dawley Triglycerides - metabolism Type 2 diabetes
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Zusammenfassung:	Gegen Qinlian Decoction (GGQLD) is one of the well-known traditional Chinese medicines. Recently, it was reported that GGQLD had good clinical effects on type 2 diabetes mellitus. However, few studies have confirmed in detail the anti-diabetic activities of GGQLD in vivo and in vitro. In the present study, we investigated the anti-diabetic effects of GGQLD in high-fat diet combined with streptozotocin-induced diabetic rats and in 3T3-L1 adipocytes. The present results suggested GGQLD (4.95, 11.55 and 18.15g/kg) decreased significantly fasting blood glucose, glycosylated serum protein, and glycosylated hemoglobin of diabetic rats (p
ISSN:	0944-7113 1618-095X
DOI:	10.1016/j.phymed.2012.11.002