Lung Function Decline in Male Heavy Smokers Relates to Baseline Airflow Obstruction Severity
Background Recent evidence indicates that the rate of lung function decline is steepest in mild COPD and slower in moderate to severe COPD. The current study assessed whether lung function decline relates to baseline airflow obstruction severity in male heavy smokers. Methods In total, 2,003 male sm...
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| Veröffentlicht in: | Chest 2012-12, Vol.142 (6), p.1530-1538 |
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| creator | Mohamed Hoesein, Firdaus A.A., MD, PhD Zanen, Pieter, MD, PhD Boezen, H. Marike, PhD Groen, Harry J.M., MD, PhD van Ginneken, Bram, PhD de Jong, Pim A., MD, PhD Postma, Dirkje S., MD, PhD Lammers, Jan-Willem J., MD, PhD |
| description | Background Recent evidence indicates that the rate of lung function decline is steepest in mild COPD and slower in moderate to severe COPD. The current study assessed whether lung function decline relates to baseline airflow obstruction severity in male heavy smokers. Methods In total, 2,003 male smokers with a mean (SD) age of 59.8 (5.3) years underwent pulmonary function testing at baseline and after 3-year follow-up. Participants were classified by entry FEV1 /FVC as follows: group 1, >70%; group 2, |
| doi_str_mv | 10.1378/chest.11-2837 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1285467562</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0012369212606874</els_id><sourcerecordid>1285467562</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-39800fa00106c5a5eb00c183c6fd614c7691f5e297f7d01df7810974646a586d3</originalsourceid><addsrcrecordid>eNpF0c9P2zAUwHFrGhod47jr5MskLgE_O7GTyyR-rBSpCGmFG5LlOs-bIU3ATor63-PQMk6WpY-frO8j5DuwYxCqPLH_MPbHABkvhfpEJlAJyESRi89kwhjwTMiK75OvMT6wdIdKfiH7nCvOuYAJuZ8P7V86HVrb-66lF2gb3yL1Lb02DdIZmvWGLlbdI4ZI_2Bjeoy07-iZifgmT31wTfdCb5axD8N2ygLXGHy_-Ub2nGkiHu7OA3I3_X17PsvmN5dX56fzzOag-kxUJWPOpN8xaQtT4JIxC6Ww0tUScqtkBa5AXimnaga1UyWwSuUyl6YoZS0OyNF27lPonofUQ698tNg0psVuiBp4WeRSFZInmm2pDV2MAZ1-Cn5lwkYD02NQ_RZUA-gxaPI_dqOH5Qrr__q9YAI_d8BEaxoXTGt9_HBScZZLmdyvrcMUYu0x6LG0T08ecYPxoRtCmxpp0JFrphfj7sbVAZdMlioXrwUMkn8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1285467562</pqid></control><display><type>article</type><title>Lung Function Decline in Male Heavy Smokers Relates to Baseline Airflow Obstruction Severity</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>Alma/SFX Local Collection</source><creator>Mohamed Hoesein, Firdaus A.A., MD, PhD ; Zanen, Pieter, MD, PhD ; Boezen, H. Marike, PhD ; Groen, Harry J.M., MD, PhD ; van Ginneken, Bram, PhD ; de Jong, Pim A., MD, PhD ; Postma, Dirkje S., MD, PhD ; Lammers, Jan-Willem J., MD, PhD</creator><creatorcontrib>Mohamed Hoesein, Firdaus A.A., MD, PhD ; Zanen, Pieter, MD, PhD ; Boezen, H. Marike, PhD ; Groen, Harry J.M., MD, PhD ; van Ginneken, Bram, PhD ; de Jong, Pim A., MD, PhD ; Postma, Dirkje S., MD, PhD ; Lammers, Jan-Willem J., MD, PhD</creatorcontrib><description>Background Recent evidence indicates that the rate of lung function decline is steepest in mild COPD and slower in moderate to severe COPD. The current study assessed whether lung function decline relates to baseline airflow obstruction severity in male heavy smokers. Methods In total, 2,003 male smokers with a mean (SD) age of 59.8 (5.3) years underwent pulmonary function testing at baseline and after 3-year follow-up. Participants were classified by entry FEV1 /FVC as follows: group 1, >70%; group 2, <70%, but greater than lower limit of normal (LLN); and group 3, less than LLN. Differences in lung function decline among the groups were assessed using multiple regression after adjustment for pack-years, smoking status (current or former smoker), presence or absence of mucus production, medical center, height, age, CT scan-derived emphysema severity (15th percentile), observation time (years in study), and the baseline values. Results Over 3 years, the mean (SD) FEV1 /FVC, FEV1 , and maximum expiratory flow at 50% of FVC decreases in group 1 were 3.1% (1), 0.21 L (0.07), and 0.40 L/s (0.26), respectively. In group 3, these decreases were 2.4% (1.1), 0.15 L (0.08), and 0.06 L/s (0.19), respectively. All lung function parameters showed the greatest decline in group 1 ( P < .001). Conclusions Diagnosing COPD based on the presence of more severe airflow obstruction (as defined by FEV1 /FVC less than LLN) means that, at the time of such a diagnosis, subjects had passed the phase of strong lung-function decline. Trial registry ISRCTN Register; No.: ISRCTN63545820; URL: www.trialregister.nl</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.11-2837</identifier><identifier>PMID: 22722231</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: American College of Chest Physicians</publisher><subject>Aged ; Airway Obstruction - physiopathology ; Biological and medical sciences ; Cardiology. Vascular system ; Follow-Up Studies ; Forced Expiratory Volume - physiology ; Humans ; Longitudinal Studies ; Lung - physiopathology ; Male ; Medical sciences ; Middle Aged ; Pneumology ; Pulmonary/Respiratory ; Regression Analysis ; Respiratory Function Tests ; Severity of Illness Index ; Smoking - adverse effects ; Vital Capacity - physiology</subject><ispartof>Chest, 2012-12, Vol.142 (6), p.1530-1538</ispartof><rights>The American College of Chest Physicians</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-39800fa00106c5a5eb00c183c6fd614c7691f5e297f7d01df7810974646a586d3</citedby><cites>FETCH-LOGICAL-c417t-39800fa00106c5a5eb00c183c6fd614c7691f5e297f7d01df7810974646a586d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26720466$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22722231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohamed Hoesein, Firdaus A.A., MD, PhD</creatorcontrib><creatorcontrib>Zanen, Pieter, MD, PhD</creatorcontrib><creatorcontrib>Boezen, H. Marike, PhD</creatorcontrib><creatorcontrib>Groen, Harry J.M., MD, PhD</creatorcontrib><creatorcontrib>van Ginneken, Bram, PhD</creatorcontrib><creatorcontrib>de Jong, Pim A., MD, PhD</creatorcontrib><creatorcontrib>Postma, Dirkje S., MD, PhD</creatorcontrib><creatorcontrib>Lammers, Jan-Willem J., MD, PhD</creatorcontrib><title>Lung Function Decline in Male Heavy Smokers Relates to Baseline Airflow Obstruction Severity</title><title>Chest</title><addtitle>Chest</addtitle><description>Background Recent evidence indicates that the rate of lung function decline is steepest in mild COPD and slower in moderate to severe COPD. The current study assessed whether lung function decline relates to baseline airflow obstruction severity in male heavy smokers. Methods In total, 2,003 male smokers with a mean (SD) age of 59.8 (5.3) years underwent pulmonary function testing at baseline and after 3-year follow-up. Participants were classified by entry FEV1 /FVC as follows: group 1, >70%; group 2, <70%, but greater than lower limit of normal (LLN); and group 3, less than LLN. Differences in lung function decline among the groups were assessed using multiple regression after adjustment for pack-years, smoking status (current or former smoker), presence or absence of mucus production, medical center, height, age, CT scan-derived emphysema severity (15th percentile), observation time (years in study), and the baseline values. Results Over 3 years, the mean (SD) FEV1 /FVC, FEV1 , and maximum expiratory flow at 50% of FVC decreases in group 1 were 3.1% (1), 0.21 L (0.07), and 0.40 L/s (0.26), respectively. In group 3, these decreases were 2.4% (1.1), 0.15 L (0.08), and 0.06 L/s (0.19), respectively. All lung function parameters showed the greatest decline in group 1 ( P < .001). Conclusions Diagnosing COPD based on the presence of more severe airflow obstruction (as defined by FEV1 /FVC less than LLN) means that, at the time of such a diagnosis, subjects had passed the phase of strong lung-function decline. Trial registry ISRCTN Register; No.: ISRCTN63545820; URL: www.trialregister.nl</description><subject>Aged</subject><subject>Airway Obstruction - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Follow-Up Studies</subject><subject>Forced Expiratory Volume - physiology</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Lung - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Pulmonary/Respiratory</subject><subject>Regression Analysis</subject><subject>Respiratory Function Tests</subject><subject>Severity of Illness Index</subject><subject>Smoking - adverse effects</subject><subject>Vital Capacity - physiology</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0c9P2zAUwHFrGhod47jr5MskLgE_O7GTyyR-rBSpCGmFG5LlOs-bIU3ATor63-PQMk6WpY-frO8j5DuwYxCqPLH_MPbHABkvhfpEJlAJyESRi89kwhjwTMiK75OvMT6wdIdKfiH7nCvOuYAJuZ8P7V86HVrb-66lF2gb3yL1Lb02DdIZmvWGLlbdI4ZI_2Bjeoy07-iZifgmT31wTfdCb5axD8N2ygLXGHy_-Ub2nGkiHu7OA3I3_X17PsvmN5dX56fzzOag-kxUJWPOpN8xaQtT4JIxC6Ww0tUScqtkBa5AXimnaga1UyWwSuUyl6YoZS0OyNF27lPonofUQ698tNg0psVuiBp4WeRSFZInmm2pDV2MAZ1-Cn5lwkYD02NQ_RZUA-gxaPI_dqOH5Qrr__q9YAI_d8BEaxoXTGt9_HBScZZLmdyvrcMUYu0x6LG0T08ecYPxoRtCmxpp0JFrphfj7sbVAZdMlioXrwUMkn8</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Mohamed Hoesein, Firdaus A.A., MD, PhD</creator><creator>Zanen, Pieter, MD, PhD</creator><creator>Boezen, H. Marike, PhD</creator><creator>Groen, Harry J.M., MD, PhD</creator><creator>van Ginneken, Bram, PhD</creator><creator>de Jong, Pim A., MD, PhD</creator><creator>Postma, Dirkje S., MD, PhD</creator><creator>Lammers, Jan-Willem J., MD, PhD</creator><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Lung Function Decline in Male Heavy Smokers Relates to Baseline Airflow Obstruction Severity</title><author>Mohamed Hoesein, Firdaus A.A., MD, PhD ; Zanen, Pieter, MD, PhD ; Boezen, H. Marike, PhD ; Groen, Harry J.M., MD, PhD ; van Ginneken, Bram, PhD ; de Jong, Pim A., MD, PhD ; Postma, Dirkje S., MD, PhD ; Lammers, Jan-Willem J., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-39800fa00106c5a5eb00c183c6fd614c7691f5e297f7d01df7810974646a586d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Airway Obstruction - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Follow-Up Studies</topic><topic>Forced Expiratory Volume - physiology</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Lung - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Pulmonary/Respiratory</topic><topic>Regression Analysis</topic><topic>Respiratory Function Tests</topic><topic>Severity of Illness Index</topic><topic>Smoking - adverse effects</topic><topic>Vital Capacity - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohamed Hoesein, Firdaus A.A., MD, PhD</creatorcontrib><creatorcontrib>Zanen, Pieter, MD, PhD</creatorcontrib><creatorcontrib>Boezen, H. Marike, PhD</creatorcontrib><creatorcontrib>Groen, Harry J.M., MD, PhD</creatorcontrib><creatorcontrib>van Ginneken, Bram, PhD</creatorcontrib><creatorcontrib>de Jong, Pim A., MD, PhD</creatorcontrib><creatorcontrib>Postma, Dirkje S., MD, PhD</creatorcontrib><creatorcontrib>Lammers, Jan-Willem J., MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohamed Hoesein, Firdaus A.A., MD, PhD</au><au>Zanen, Pieter, MD, PhD</au><au>Boezen, H. Marike, PhD</au><au>Groen, Harry J.M., MD, PhD</au><au>van Ginneken, Bram, PhD</au><au>de Jong, Pim A., MD, PhD</au><au>Postma, Dirkje S., MD, PhD</au><au>Lammers, Jan-Willem J., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lung Function Decline in Male Heavy Smokers Relates to Baseline Airflow Obstruction Severity</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>142</volume><issue>6</issue><spage>1530</spage><epage>1538</epage><pages>1530-1538</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Background Recent evidence indicates that the rate of lung function decline is steepest in mild COPD and slower in moderate to severe COPD. The current study assessed whether lung function decline relates to baseline airflow obstruction severity in male heavy smokers. Methods In total, 2,003 male smokers with a mean (SD) age of 59.8 (5.3) years underwent pulmonary function testing at baseline and after 3-year follow-up. Participants were classified by entry FEV1 /FVC as follows: group 1, >70%; group 2, <70%, but greater than lower limit of normal (LLN); and group 3, less than LLN. Differences in lung function decline among the groups were assessed using multiple regression after adjustment for pack-years, smoking status (current or former smoker), presence or absence of mucus production, medical center, height, age, CT scan-derived emphysema severity (15th percentile), observation time (years in study), and the baseline values. Results Over 3 years, the mean (SD) FEV1 /FVC, FEV1 , and maximum expiratory flow at 50% of FVC decreases in group 1 were 3.1% (1), 0.21 L (0.07), and 0.40 L/s (0.26), respectively. In group 3, these decreases were 2.4% (1.1), 0.15 L (0.08), and 0.06 L/s (0.19), respectively. All lung function parameters showed the greatest decline in group 1 ( P < .001). Conclusions Diagnosing COPD based on the presence of more severe airflow obstruction (as defined by FEV1 /FVC less than LLN) means that, at the time of such a diagnosis, subjects had passed the phase of strong lung-function decline. Trial registry ISRCTN Register; No.: ISRCTN63545820; URL: www.trialregister.nl</abstract><cop>Northbrook, IL</cop><pub>American College of Chest Physicians</pub><pmid>22722231</pmid><doi>10.1378/chest.11-2837</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Airway Obstruction - physiopathology Biological and medical sciences Cardiology. Vascular system Follow-Up Studies Forced Expiratory Volume - physiology Humans Longitudinal Studies Lung - physiopathology Male Medical sciences Middle Aged Pneumology Pulmonary/Respiratory Regression Analysis Respiratory Function Tests Severity of Illness Index Smoking - adverse effects Vital Capacity - physiology |
| title | Lung Function Decline in Male Heavy Smokers Relates to Baseline Airflow Obstruction Severity |
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