Lung Function Decline in Male Heavy Smokers Relates to Baseline Airflow Obstruction Severity

Background Recent evidence indicates that the rate of lung function decline is steepest in mild COPD and slower in moderate to severe COPD. The current study assessed whether lung function decline relates to baseline airflow obstruction severity in male heavy smokers. Methods In total, 2,003 male sm...

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Veröffentlicht in:	Chest 2012-12, Vol.142 (6), p.1530-1538
Hauptverfasser:	Mohamed Hoesein, Firdaus A.A., MD, PhD, Zanen, Pieter, MD, PhD, Boezen, H. Marike, PhD, Groen, Harry J.M., MD, PhD, van Ginneken, Bram, PhD, de Jong, Pim A., MD, PhD, Postma, Dirkje S., MD, PhD, Lammers, Jan-Willem J., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Airway Obstruction - physiopathology Biological and medical sciences Cardiology. Vascular system Follow-Up Studies Forced Expiratory Volume - physiology Humans Longitudinal Studies Lung - physiopathology Male Medical sciences Middle Aged Pneumology Pulmonary/Respiratory Regression Analysis Respiratory Function Tests Severity of Illness Index Smoking - adverse effects Vital Capacity - physiology
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Zusammenfassung:	Background Recent evidence indicates that the rate of lung function decline is steepest in mild COPD and slower in moderate to severe COPD. The current study assessed whether lung function decline relates to baseline airflow obstruction severity in male heavy smokers. Methods In total, 2,003 male smokers with a mean (SD) age of 59.8 (5.3) years underwent pulmonary function testing at baseline and after 3-year follow-up. Participants were classified by entry FEV1 /FVC as follows: group 1, >70%; group 2,
ISSN:	0012-3692 1931-3543
DOI:	10.1378/chest.11-2837