Cathelicidin gene therapy: a new therapeutic option in ulcerative colitis and beyond?

The possibility that cathelicidin gene therapy could emerge as a new therapeutic option for ulcerative colitis and other diseases is examined. The broad spectrum of cathelicidin antimicrobial activity, the low incidence of bacterial resistance and their function as immunomodulatory agents are attrac...

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Veröffentlicht in:	Gene therapy 2013-02, Vol.20 (2), p.119-120
Hauptverfasser:	Ahluwalia, A, Tarnawski, A S
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/51/201 631/45/612/1237 692/699/1503/257/1389 Animals Antimicrobial Cationic Peptides - genetics Biomedical and Life Sciences Biomedicine Care and treatment Cell Biology Colitis, Ulcerative - therapy Gene Expression Gene Therapy Genetic aspects Genetic Therapy Human Genetics Immunology Inflammatory bowel disease Methods Nanotechnology news-and-commentary Peptides Physiological aspects Ulcerative colitis
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Beschreibung
Zusammenfassung:	The possibility that cathelicidin gene therapy could emerge as a new therapeutic option for ulcerative colitis and other diseases is examined. The broad spectrum of cathelicidin antimicrobial activity, the low incidence of bacterial resistance and their function as immunomodulatory agents are attractive features of cathelicidins for their potential clinical use.
ISSN:	0969-7128 1476-5462
DOI:	10.1038/gt.2012.23