Antiepileptic Drugs and Bone Metabolism in Children: Data from 128 Patients

There are conflicting results concerning bone metabolism in children receiving antiepileptic medication, with data concentrating on neurologically impaired patients. We performed a multicenter cross-sectional study in otherwise healthy children who received monotherapy with valproic acid, oxcarbazep...

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Veröffentlicht in:	Journal of child neurology 2013-02, Vol.28 (2), p.176-183
Hauptverfasser:	Borusiak, Peter, Langer, Thorsten, Heruth, Marion, Karenfort, Michael, Bettendorf, Ulrich, Jenke, Andreas CW
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Analysis of Variance Anthropometry Anticonvulsants - adverse effects Bone and Bones - drug effects Bone and Bones - metabolism Calcium - metabolism Child Child, Preschool Cohort Studies Cross-Sectional Studies Epilepsy - blood Epilepsy - drug therapy Epilepsy - epidemiology Epilepsy - pathology Female Humans Hypocalcemia - chemically induced Hypophosphatemia - chemically induced Infant Male Retrospective Studies Vitamin D Deficiency - chemically induced
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Beschreibung
Zusammenfassung:	There are conflicting results concerning bone metabolism in children receiving antiepileptic medication, with data concentrating on neurologically impaired patients. We performed a multicenter cross-sectional study in otherwise healthy children who received monotherapy with valproic acid, oxcarbazepine, lamotrigine, sulthiame, levetiracetam, or topiramate for at least 6 months. Data on calcium, phosphorus, alkaline phosphatase, 25-OH vitamin D, and parathormone were collected. Among 128 patients, 24.4% had hypocalcemia, 25.4% hypophosphatemia, and 13.3% (n = 17) 25-OH vitamin D levels
ISSN:	0883-0738 1708-8283
DOI:	10.1177/0883073812443005