Enhanced costimulation by CD70 + B cells aggravates experimental autoimmune encephalomyelitis in autoimmune mice

Abstract Objective Assess whether CD70 + B cells contribute to EAE. Materials and methods MOG-specific TCR transgenic mice (2D2) were crossed with mice with constitutive CD70 expression on B cells. The development of EAE and the phenotype of B-T lymphocytes were studied in 2D2xCD70 animals. Results Spontaneous EAE developed in 20% of 2D2xCD70 and 3% of 2D2 mice. EAE was also more severe in 2D2xCD70 versus 2D2 animals upon MOG immunization. The susceptibility of 2D2xCD70 to EAE was associated with fewer FoxP3 + T cells. Conclusions Expression of CD70 by B cells aggravates EAE possibly by reducing the number of regulatory T cells.