Virus-like particles displaying envelope domain III of dengue virus type 2 induce virus-specific antibody response in mice

Highlights ► Fusion antigen with dengue virus EDIII in c/e1 loop of HBV core antigen created. ► Yeast-expressed fusion antigen assembled into virus-like particles. ► EDIII moiety on chimeric virus-like particle was accessible to specific antibodies. ► Chimeric virus-like particles induced dengue vir...

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Veröffentlicht in:	Vaccine 2013-01, Vol.31 (6), p.873-878
Hauptverfasser:	Arora, Upasana, Tyagi, Poornima, Swaminathan, Sathyamangalam, Khanna, Navin
Format:	Artikel
Sprache:	eng
Schlagworte:	affinity chromatography alcohol oxidase Allergy and Immunology Animals antibodies Antibodies, Neutralizing - blood Antibodies, Viral - blood Applied microbiology Arboviroses Biological and medical sciences chimerism Chromatography dengue Dengue envelope domain III Dengue fevers Dengue vaccine Dengue Vaccines - administration & dosage Dengue Vaccines - genetics Dengue Vaccines - immunology Dengue virus Dengue Virus - genetics Dengue Virus - immunology Dengue virus type 2 Drug Carriers - administration & dosage E coli electron microscopy enzyme-linked immunosorbent assay Fundamental and applied biological sciences. Psychology genes hepatitis B antigens Hepatitis B Surface Antigens - genetics Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus core antigen hepatitis C antigens Human viral diseases humoral immunity Infectious diseases Medical research Medical sciences methanol Mice Mice, Inbred BALB C Microbiology Microscopy, Electron Miscellaneous Molecular Sequence Data neutralization nickel pathogenicity Pichia Pichia pastoris Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Sequence Analysis, DNA Tropical viral diseases Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccines, Virus-Like Particle - administration & dosage Vaccines, Virus-Like Particle - genetics Vaccines, Virus-Like Particle - immunology Vector-borne diseases Viral diseases Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Virology Virus-like particle virus-like particles Yeast Yeasts
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Beschreibung
Zusammenfassung:	Highlights ► Fusion antigen with dengue virus EDIII in c/e1 loop of HBV core antigen created. ► Yeast-expressed fusion antigen assembled into virus-like particles. ► EDIII moiety on chimeric virus-like particle was accessible to specific antibodies. ► Chimeric virus-like particles induced dengue virus-specific antibody response in mice.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.12.016