Mycobacterium tuberculosis modulators of the macrophage's cellular events

A number of mycobacterial macromolecules have been shown to target biological processes within host macrophages; however, the exact mechanism for the majority of these host–pathogen interactions is poorly understood. The following review summarizes current knowledge and expands on a subset of mycoba...

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Veröffentlicht in:Microbes and infection 2012-11, Vol.14 (13), p.1211-1219
Hauptverfasser: Poirier, Valérie, Av-Gay, Yossef
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container_title Microbes and infection
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creator Poirier, Valérie
Av-Gay, Yossef
description A number of mycobacterial macromolecules have been shown to target biological processes within host macrophages; however, the exact mechanism for the majority of these host–pathogen interactions is poorly understood. The following review summarizes current knowledge and expands on a subset of mycobacterial effectors for which a cognate substrate, cellular partner or signaling pathway have been experimentally identified within the human host.
doi_str_mv 10.1016/j.micinf.2012.07.001
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Antigen Presentation
Antigen processing and presentation
Bacterial Proteins - immunology
Bacterial Proteins - metabolism
Bacteriology
Biological and medical sciences
Cell trafficking
Fundamental and applied biological sciences. Psychology
Host-Pathogen Interactions
Humans
Macromolecules
Macrophages
Macrophages - immunology
Macrophages - microbiology
Macrophages - physiology
Microbiology
Miscellaneous
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Mycobacterium tuberculosis - pathogenicity
Mycobacterium tuberculosis - physiology
Phagosome maturation
Phagosomes - immunology
Phagosomes - microbiology
Phagosomes - physiology
Reviews
Signal transduction
Signal Transduction - immunology
Signal Transduction - physiology
Tuberculosis
Tuberculosis - immunology
Tuberculosis - microbiology
title Mycobacterium tuberculosis modulators of the macrophage's cellular events
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