Mycobacterium tuberculosis modulators of the macrophage's cellular events

A number of mycobacterial macromolecules have been shown to target biological processes within host macrophages; however, the exact mechanism for the majority of these host–pathogen interactions is poorly understood. The following review summarizes current knowledge and expands on a subset of mycoba...

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Veröffentlicht in:	Microbes and infection 2012-11, Vol.14 (13), p.1211-1219
Hauptverfasser:	Poirier, Valérie, Av-Gay, Yossef
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen Presentation Antigen processing and presentation Bacterial Proteins - immunology Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Cell trafficking Fundamental and applied biological sciences. Psychology Host-Pathogen Interactions Humans Macromolecules Macrophages Macrophages - immunology Macrophages - microbiology Macrophages - physiology Microbiology Miscellaneous Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity Mycobacterium tuberculosis - physiology Phagosome maturation Phagosomes - immunology Phagosomes - microbiology Phagosomes - physiology Reviews Signal transduction Signal Transduction - immunology Signal Transduction - physiology Tuberculosis Tuberculosis - immunology Tuberculosis - microbiology
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Beschreibung
Zusammenfassung:	A number of mycobacterial macromolecules have been shown to target biological processes within host macrophages; however, the exact mechanism for the majority of these host–pathogen interactions is poorly understood. The following review summarizes current knowledge and expands on a subset of mycobacterial effectors for which a cognate substrate, cellular partner or signaling pathway have been experimentally identified within the human host.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/j.micinf.2012.07.001