An allergic phenotype and the use of steroid inhalers predict eosinophilic oesophagitis in patients with asthma

Summary Background Patients with eosinophilic oesophagitis (EoE) commonly have asthma and atopy. Aims To determine the predictive factors of EoE in patients with asthma. Methods A retrospective analysis of a large database identified 156 asthma patients with EoE and 276 patients without EoE between...

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Veröffentlicht in:	Alimentary pharmacology & therapeutics 2013-01, Vol.37 (1), p.107-113
Hauptverfasser:	Harer, K. N., Enders, F. T., Lim, K. G., Alexander, J. A., Katzka, D. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergens - immunology Allergic rhinitis Asthma Asthma - drug therapy Atopy Biological and medical sciences Chronic obstructive pulmonary disease, asthma Corticoids Digestive system Dysphagia Eosinophilia Eosinophilia - diagnosis Eosinophilic Esophagitis - diagnosis Eosinophilic Esophagitis - prevention & control Esophagus Female Food hypersensitivity Gastroenterology. Liver. Pancreas. Abdomen Glucocorticoids - administration & dosage Hematologic and hematopoietic diseases Humans Leukocytes (eosinophilic) Logistic Models Male Medical sciences Nebulizers and Vaporizers Other diseases. Hematologic involvement in other diseases Other diseases. Semiology Pharmacology. Drug treatments Phenotype Pneumology Predictive Value of Tests Regression analysis Retrospective Studies Rhinitis, Allergic Rhinitis, Allergic, Perennial - diagnosis Steroid hormones
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Zusammenfassung:	Summary Background Patients with eosinophilic oesophagitis (EoE) commonly have asthma and atopy. Aims To determine the predictive factors of EoE in patients with asthma. Methods A retrospective analysis of a large database identified 156 asthma patients with EoE and 276 patients without EoE between 2000 and 2010. Clinical and laboratory characteristics were first analyzed in half of each group. Significant differences and modelling were then applied to the other half of each group in a split half analysis. Results Odds ratios and P‐values found to predict the presence of EoE in asthma patients were: allergic vs. non‐allergic asthma (4.07,
ISSN:	0269-2813 1365-2036
DOI:	10.1111/apt.12131