Correlation between molecular heterogeneity of ceruloplasmin mRNA and ceruloplasmin isomers synthesized in rat liver

Correlation between molecular heterogeneity of ceruloplasmin mRNA and ceruloplasmin isomers synthesized in rat liver

Molecular heterogeneity of ceruloplasmin mRNA is studied in rat liver polyribosomes. Blot hybridization of RNA with cDNA reveals three molecular forms of ceruloplasmin mRNA differing in the chain length and structure of the 3'-regions. A correlation between these mRNAs and three isoforms of cer...

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Veröffentlicht in:Bulletin of experimental biology and medicine 1997-01, Vol.123 (1), p.68-70
Hauptverfasser: Tsymbalenko, N. V., Aleinikova, T. D., Puchkova, L. V., Gaitskhoki, V. S.
Format: Artikel
Sprache:eng
Schlagworte:
Ceruloplasmin
Copper
Isomers
Liver
mRNA
Polyribosomes
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Zusammenfassung:Molecular heterogeneity of ceruloplasmin mRNA is studied in rat liver polyribosomes. Blot hybridization of RNA with cDNA reveals three molecular forms of ceruloplasmin mRNA differing in the chain length and structure of the 3'-regions. A correlation between these mRNAs and three isoforms of ceruloplasmin, which perform different functions in the copper transport, is established.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02764384