Serum-Mediated Inhibition of the Interferon-Gamma-Induced HLA-DR Expression on Monocytes in Patient with Psoriasis

Psoriatic patients have a decreased proportion of monocytes expressing class II major histocompatibility complex antigens (DR+ monocytes) in their peripheral blood. The expression of the DR antigen on monocytes after culture in the presence of either autologous lymphocytes (endogenous interferon-gam...

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Veröffentlicht in:Journal of investigative dermatology 1986-10, Vol.87 (4), p.524-527
Hauptverfasser: Volk, Hans-Dieter, Koyka, Ingrid, Goan, Silvia-Renate, Gruner, Stefan, Fiebig, Helmut, Sönnichsen, Niels, Diezel, Wolfgang
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Sprache:eng
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Zusammenfassung:Psoriatic patients have a decreased proportion of monocytes expressing class II major histocompatibility complex antigens (DR+ monocytes) in their peripheral blood. The expression of the DR antigen on monocytes after culture in the presence of either autologous lymphocytes (endogenous interferon-gamma, IFN-γ) or exogenous IFN-γ was investigated. In normal AB serum the lymphocytes of the majority of the patients showed a spontaneous IFN-γ production which was sufficient for DR antigen induction, while the monocytes displayed approximate normal susceptibility to exogenous IFN-γ as judged by DR antigen expression. However, the sera of psoriatic patients contained one or more factors that interfered with the lFN-γ- mediated DR antigen expression on cultured monocytes of the same patients. Restoration of IFN-γ-induced DR antigen expression on monocytes in the presence of the patient's sera was achieved by the addition of superoxide dismutase, 2-mercaptoethanol, or indomethacin. The clinical significance of these observations is discussed.
ISSN:0022-202X
1523-1747
DOI:10.1111/1523-1747.ep12455607