Pd-Catalyzed P–C Cross-Coupling Reactions for Versatile Triarylphosphine Synthesis

Pd-Catalyzed P–C Cross-Coupling Reactions for Versatile Triarylphosphine Synthesis

Practical and versatile syntheses of tertiary phosphine derivatives have been achieved by palladium-catalyzed deformylative P–C cross-coupling reactions of hydroxymethylphosphine derivatives. Sequential couplings of orthogonally protected precursors provide a simple and practical route toward a vari...

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Veröffentlicht in:Organic letters 2013-02, Vol.15 (3), p.628-631
Hauptverfasser: Hayashi, Minoru, Matsuura, Takashi, Tanaka, Ippei, Ohta, Hidetoshi, Watanabe, Yutaka
Format: Artikel
Sprache:eng
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Zusammenfassung:Practical and versatile syntheses of tertiary phosphine derivatives have been achieved by palladium-catalyzed deformylative P–C cross-coupling reactions of hydroxymethylphosphine derivatives. Sequential couplings of orthogonally protected precursors provide a simple and practical route toward a variety of tertiary phosphine derivatives having aryl substituents in any combination.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol303448j