Effect of catalytic alkali metal bromide on Hofmann-type rearrangement of imides

Effect of catalytic alkali metal bromide on Hofmann-type rearrangement of imides

The Hofmann-type rearrangement of aromatic and aliphatic imides using KBr as the catalyst proceeded to provide aromatic and aliphatic amino acid derivatives. We have also developed a new synthetic route to gabapentin with this method.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (68), p.8574-8576
Hauptverfasser: Moriyama, Katsuhiko, Ishida, Kazuma, Togo, Hideo
Format: Artikel
Sprache:eng
Schlagworte:
Aliphatic compounds
Alkali metals
Amines - chemical synthesis
Amines - chemistry
Amino acids
Bromides
Bromides - chemistry
Catalysis
Catalysts
Cyclohexanecarboxylic Acids - chemical synthesis
Cyclohexanecarboxylic Acids - chemistry
Derivatives
gamma-Aminobutyric Acid - chemical synthesis
gamma-Aminobutyric Acid - chemistry
Imides
Imides - chemistry
Metals, Alkali - chemistry
Oxidation-Reduction
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Beschreibung
Zusammenfassung:The Hofmann-type rearrangement of aromatic and aliphatic imides using KBr as the catalyst proceeded to provide aromatic and aliphatic amino acid derivatives. We have also developed a new synthetic route to gabapentin with this method.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc33914e