A method for the synthesis of pyridines from aldehydes, alkynes and NH sub(4)OAc involving Rh-catalyzed hydroacylation and N-annulation

A method for the synthesis of pyridines from aldehydes, alkynes and NH sub(4)OAc involving Rh-catalyzed hydroacylation and N-annulation

A new method for regiocontrolled pyridine synthesis has been developed involving sequential Rh(i)-catalyzed chelation-assisted hydroacylation of alkynes with aldehydes followed by Rh(iii)-promoted N-annulation of the resulting alpha , beta -enones with another alkyne and NH sub(3).

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-11, Vol.48 (96), p.11787-11789
Hauptverfasser: Sim, Yong-Kyun, Lee, Hyejeong, Park, Jung-Woo, Kim, Dong-Su, Jun, Chul-Ho
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Alkynes
Chelating
Pyridines
Synthesis
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Beschreibung
Zusammenfassung:A new method for regiocontrolled pyridine synthesis has been developed involving sequential Rh(i)-catalyzed chelation-assisted hydroacylation of alkynes with aldehydes followed by Rh(iii)-promoted N-annulation of the resulting alpha , beta -enones with another alkyne and NH sub(3).
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc36956g