Monitoring the aggregation processes of amyloid-[small beta] using a spin-labeled, fluorescent nitroxyl radical

Monitoring the aggregation processes of amyloid-[small beta] using a spin-labeled, fluorescent nitroxyl radical

Amyloid nitroxyl radical (nitroxide) ligands were used to detect amyloid-[small beta] fibrils, the main constituents of senile plaques in Alzheimer's disease, using anisotropic ESR spectra, and were found to affect the aggregation process due to the radical functionality. These compounds have g...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (17), p.5070-5072
Hauptverfasser: Mito, Fumiya, Yamasaki, Toshihide, Ito, Yuko, Yamato, Mayumi, Mino, Hiroyuki, Sadasue, Hiromi, Shirahama, Chisato, Sakai, Kiyoshi, Utsumi, Hideo, Yamada, Ken-ichi
Format: Artikel
Sprache:eng
Schlagworte:
Agglomeration
Alzheimer's disease
Beta
Fluorescence
Ligands
Monitoring
Radicals
Spectra
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Amyloid nitroxyl radical (nitroxide) ligands were used to detect amyloid-[small beta] fibrils, the main constituents of senile plaques in Alzheimer's disease, using anisotropic ESR spectra, and were found to affect the aggregation process due to the radical functionality. These compounds have great potential as novel and multifunctional probes, combining spin labels, spin probes, and fluorescence probes.
ISSN:1359-7345
DOI:10.1039/C0CC05764A