Impact of telemedicine assessment on glycemic variability in children with type 1 diabetes mellitus

Experimental and in vitro studies have related glycemic variability (GV) with activation of oxidative stress, which could be involved in the micro- and macrovascular damage found in diabetes mellitus and in acute complications such as hypoglycemia. Some GV indexes are currently integrated in specialized Web sites for the analysis and assessment of diabetes patients through telemedicine. We aimed to identify the impact of telemedicine on metabolic control and GV in prepubescent patients with type 1 diabetes mellitus (T1DM). Eighty patients between 6 and 10 years old were eligible for enrollment. Participation was accepted by the parents of only 15 (18%) patients, of whom 13 (86%) completed the study. These 13 patients were assessed fortnightly for 3 months through Accu-Chek (Roche, Mannheim, Germany) Smart Pix software; this period was compared with a subsequent 4-month period without telemedical support. The variables analyzed were mean glycated hemoglobin (HbA1c), mean blood glucose (MBG), and indexes of GV (SD, low blood glucose index [LBGI], high blood glucose index [HBGI], and the average daily risk range [ADRR]). In both periods, the patients attended their regular appointments. The statistical analysis was carried out with nonparametric tests (the Wilcoxon and Friedman tests, P