HuPho: the human phosphatase portal

Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. Phosphorylation is a key post‐translational modification underlying the regulation of many cellular processes. Thus, a comprehensive picture of phosphatase function and the identification of their target substrates would aid a systematic approach to a mechanistic description of cell signalling. Here we present a website designed to facilitate the retrieval of information about human protein phosphatases. To this end we developed a search engine to recover and integrate information annotated in several publicly available web resources. In addition we present a text‐mining‐assisted annotation effort aimed at extracting phosphatase related data reported in the scientific literature. The HuPho (human phosphatases) website can be accessed at http://hupho.uniroma2.it. Phosphorylation is a key post‐translational modification underlying the regulation of many cellular processes: a comprehensive picture of phosphatases’ function and the identification of their target substrates would aid a systematic approach to a mechanistic description of cell signaling. Here we present a web site named HuPho (http://hupho.uniroma2.it), designed to retrieve information about human protein phosphatases from publicly available resources.