Angiotensin (5–8) modulates nociception at the rat periaqueductal gray via the NO–sGC pathway and an endogenous opioid

Highlights ► Ang (5–8) injection into PAG selectively elicits Ang-R-mediated antinociception. ► The PAG both synthesizes and inactivates Ang (5–8). ► Ang (5–8) modulates antinociception via NO–sGC pathway and opioid. ► Ang (5–8) antinociception is 74-fold more potent than that of morphine. ► Ang (5–...

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Veröffentlicht in:	Neuroscience 2013-02, Vol.231, p.315-327
Hauptverfasser:	Guethe, L.M, Pelegrini-da-Silva, A, Borelli, K.G, Juliano, M.A, Pelosi, G.G, Pesquero, J.B, Silva, C.L.M, Corrêa, F.M.A, Murad, F, Prado, W.A, Martins, A.R
Format:	Artikel
Sprache:	eng
Schlagworte:	angiotensin (5–8) Angiotensin I - pharmacology Angiotensin Receptor Antagonists - pharmacology Animals antinociception Aorta - drug effects Dose-Response Relationship, Drug Guanylate Cyclase - metabolism Heart Rate - physiology incision allodynia model Male Muscle Contraction - drug effects Muscle, Smooth - drug effects Neurology Nitric Oxide - metabolism Nociception - drug effects Opioid Peptides - antagonists & inhibitors Opioid Peptides - metabolism pain Peptide Fragments - pharmacology Periaqueductal Gray - drug effects periaqueductal gray matter Rats Rats, Wistar Receptors, Cytoplasmic and Nuclear - metabolism Saralasin - pharmacology Signal Transduction - drug effects Soluble Guanylyl Cyclase tail-flick test Teprotide - pharmacology
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Zusammenfassung:	Highlights ► Ang (5–8) injection into PAG selectively elicits Ang-R-mediated antinociception. ► The PAG both synthesizes and inactivates Ang (5–8). ► Ang (5–8) modulates antinociception via NO–sGC pathway and opioid. ► Ang (5–8) antinociception is 74-fold more potent than that of morphine. ► Ang (5–8) can be a leading compound to develop potent and selective analgesic drugs.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.11.048