Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells

Highlights ► Fndc5 knockdown was performed in two stages. ► Fndc5 knockdown during both stages affected neuronal and astrocytes maturation ► Fndc5 expression is required for the appropriate neural differentiation.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2013-02, Vol.231, p.296-304
Hauptverfasser:	Hashemi, M.-S, Ghaedi, K, Salamian, A, Karbalaie, K, Emadi-Baygi, M, Tanhaei, S, Nasr-Esfahani, M.H, Baharvand, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Development. Senescence. Regeneration. Transplantation Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Fibronectins - genetics Fibronectins - metabolism Fndc5 Fundamental and applied biological sciences. Psychology Mice Mice, Inbred C57BL neurogenesis Neurogenesis - genetics Neurology Neurons - cytology Neurons - metabolism peroxisomal protein RNAi Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► Fndc5 knockdown was performed in two stages. ► Fndc5 knockdown during both stages affected neuronal and astrocytes maturation ► Fndc5 expression is required for the appropriate neural differentiation.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.11.041