Renal Sympathetic Denervation Does Not Aggravate Functional or Structural Renal Damage

[...]we also analyzed urinary NGAL and KIM-1 concentrations for the early and highly sensitive detection of subsequent functional and structural kidney damage with the potential for progression within the first days, as well as 3 months after RSD. Time Points after RSD) 24 Hours 48 Hours 3 Months 1...

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Veröffentlicht in:	Journal of the American College of Cardiology 2013-01, Vol.61 (4), p.479-480
Hauptverfasser:	Dörr, Oliver, MD, Liebetrau, Christoph, MD, Möllmann, Helge, MD, Achenbach, Stephan, MD, Sedding, Daniel, MD, Szardien, Sebastian, MD, Willmer, Matthias, MD, Rixe, Johannes, MD, Troidl, Christian, PhD, Elsässer, Albrecht, MD, Hamm, Christian, MD, Nef, Holger M., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - diagnosis Acute Kidney Injury - etiology Acute-Phase Proteins - urine Aged Biological and medical sciences Biomarkers Biomarkers - urine Blood Pressure Monitoring, Ambulatory Cardiology Cardiology. Vascular system Cardiovascular Creatinine Denervation Drug Resistance, Multiple Epidermal growth factor receptors Female Gelatinase Glomerular filtration rate Hepatitis A Virus Cellular Receptor 1 Humans Hypertension Hypertension - physiopathology Hypertension - therapy Internal Medicine Kidney - innervation Kidney - metabolism Kidney - physiopathology Kidney diseases Kidney Function Tests - methods Kidneys Laboratories Lipocalin Lipocalin-2 Lipocalins - urine Male Medical sciences Membrane Glycoproteins - urine Middle Aged Nitrogen Postoperative Complications - diagnosis Proto-Oncogene Proteins - urine Receptors, Virus Structure-function relationships Studies Sympathectomy - adverse effects Sympathectomy - methods Sympathetic Nervous System - surgery Treatment Outcome Urea
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Zusammenfassung:	[...]we also analyzed urinary NGAL and KIM-1 concentrations for the early and highly sensitive detection of subsequent functional and structural kidney damage with the potential for progression within the first days, as well as 3 months after RSD. Time Points after RSD) 24 Hours 48 Hours 3 Months 1 Day 2 Days 3 Months Creatinine (mg/dl) 0.90(IQR:0.80-1.11) 0.90(IQR:0.74-1.10) 0.95(IQR:0.82-1.35) 0.85(IQR:0.80-1.10) 0.12 0.26 0.24 eGFR (ml/min/1.73 m2) 79.3±27.3 81.2±24.6 72.5±24.4 79.5±16.8 0.41 0.18 0.71 BUN (mg/dl) 39.0(IQR:31.8-54.3) 36.0(IQR:30.0-48.0) 47.0(IQR:30.0-59.0) 39.0(IQR:30.5-51.0) 0.41 0.19 0.69 Urinary NGAL (ng/ml) 16.9(IQR:6.8-34.1) 14.0(IQR:6.2-39.8) 14.0(IQR:4.7-35.8) 13.3(IQR:4.8-27.9) 0.67 0.65 0.59 KIM-1 (ng/ml) 0.65(IQR:0.30-0.95) 0.53(IQR:0.37-0.82) 0.61(IQR:0.38-0.81) 0.61(IQR:0.38-0.81) 0.54 0.78 0.77 Table 3 Laboratory Measurements BUN = blood urea nitrogen; eGFR = estimated glomerular filtration rate; IQR = interquartile range; KIM-1 = kidney injury molecule-1; NGAL = neurophil gelatinase-associated lipocalin; RSD = renal sympathetic denervation.
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2012.09.051