Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines

Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines

The first catalytic asymmetric pseudo five-component (AB(2)C(2) type) reaction is reported. A spirocyclic chiral phosphoric acid catalyzed one-pot multicomponent reaction of aromatic aldehydes, anilines and β-ketoesters and afforded highly functionalized enantioenriched tetrahydropyridines with high...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-02, Vol.49 (14), p.1401-1403
Hauptverfasser: Li, Xuejian, Zhao, Yanyan, Qu, Haijun, Mao, Zhenjun, Lin, Xufeng
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes - chemistry
Aniline Compounds - chemistry
Catalysis
Esters
Phosphoric Acids - chemistry
Pyridines - chemical synthesis
Pyridines - chemistry
Spiro Compounds - chemistry
Stereoisomerism
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container_end_page 1403
container_issue 14
container_start_page 1401
container_title Chemical communications (Cambridge, England)
container_volume 49
creator Li, Xuejian
Zhao, Yanyan
Qu, Haijun
Mao, Zhenjun
Lin, Xufeng
description The first catalytic asymmetric pseudo five-component (AB(2)C(2) type) reaction is reported. A spirocyclic chiral phosphoric acid catalyzed one-pot multicomponent reaction of aromatic aldehydes, anilines and β-ketoesters and afforded highly functionalized enantioenriched tetrahydropyridines with high levels of stereocontrol.
doi_str_mv 10.1039/c2cc38349g
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source MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Aldehydes - chemistry
Aniline Compounds - chemistry
Catalysis
Esters
Phosphoric Acids - chemistry
Pyridines - chemical synthesis
Pyridines - chemistry
Spiro Compounds - chemistry
Stereoisomerism
title Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines
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