Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines

The first catalytic asymmetric pseudo five-component (AB(2)C(2) type) reaction is reported. A spirocyclic chiral phosphoric acid catalyzed one-pot multicomponent reaction of aromatic aldehydes, anilines and β-ketoesters and afforded highly functionalized enantioenriched tetrahydropyridines with high...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-02, Vol.49 (14), p.1401-1403
Hauptverfasser:	Li, Xuejian, Zhao, Yanyan, Qu, Haijun, Mao, Zhenjun, Lin, Xufeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - chemistry Aniline Compounds - chemistry Catalysis Esters Phosphoric Acids - chemistry Pyridines - chemical synthesis Pyridines - chemistry Spiro Compounds - chemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	The first catalytic asymmetric pseudo five-component (AB(2)C(2) type) reaction is reported. A spirocyclic chiral phosphoric acid catalyzed one-pot multicomponent reaction of aromatic aldehydes, anilines and β-ketoesters and afforded highly functionalized enantioenriched tetrahydropyridines with high levels of stereocontrol.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c2cc38349g