[18F]fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): application to 6-[18F]fluoro-L-DOPA

The Ag-mediated electrophilic [(18)F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [(18)F]selectfluor bis(triflate) in acetone. The process gave 6-[(18)F]fluoro-L-DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol(-1).

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-02, Vol.49 (14), p.1386-1388
Hauptverfasser:	Stenhagen, Ida S R, Kirjavainen, Anna K, Forsback, Sarita J, Jørgensen, Charlotte G, Robins, Edward G, Luthra, Sajinder K, Solin, Olof, Gouverneur, Véronique
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetone - chemistry Boronic Acids - chemistry Diazonium Compounds - chemistry Esters Fluorine Radioisotopes - chemistry Halogenation Levodopa - chemistry Silver - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The Ag-mediated electrophilic [(18)F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [(18)F]selectfluor bis(triflate) in acetone. The process gave 6-[(18)F]fluoro-L-DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol(-1).
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c2cc38646a