Immune evasion strategies of flaviviruses

Immune evasion strategies of flaviviruses

Highlights ► Flaviviruses have evolved a variety of strategies to modulate the immune responses of host. ► Mechanisms by which flaviviruses evade the innate and adaptive immunity of the host are summarized based on current studies. ► Flaviviruses limit type I IFN signaling by blocking the host gene...

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Veröffentlicht in:Vaccine 2013-01, Vol.31 (3), p.461-471
Hauptverfasser: Ye, Jing, Zhu, Bibo, Fu, Zhen F, Chen, Huanchun, Cao, Shengbo
Format: Artikel
Sprache:eng
Schlagworte:
Adaptive immunity
Allergy and Immunology
Animals
Applied microbiology
Biological and medical sciences
complement
Dengue virus
Encephalitis
Flaviviridae
Flavivirus
Flavivirus - immunology
Flavivirus - pathogenicity
Fundamental and applied biological sciences. Psychology
Host-Pathogen Interactions
hosts
Humans
Immune Evasion
Immune response
Immune system
Innate immunity
interferons
Japanese encephalitis virus
Medical research
Microbiology
Miscellaneous
morbidity
mortality
pathogenesis
T cell receptors
T-lymphocytes
therapeutics
Tick-borne encephalitis virus
vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral infections
Virology
viruses
West Nile virus
Yellow fever virus
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Beschreibung
Zusammenfassung:Highlights ► Flaviviruses have evolved a variety of strategies to modulate the immune responses of host. ► Mechanisms by which flaviviruses evade the innate and adaptive immunity of the host are summarized based on current studies. ► Flaviviruses limit type I IFN signaling by blocking the host gene expression, thus attenuating innate immunity. ► Flaviviruses also inhibit the antiviral immune response of complement system and NK cells. ► High genetic variability of viral antigens allows viral escape from both humoral and cellular immunity against flaviviruses.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.11.015