Proinflammatory cytokines induced altered expression of cyclooxygenase-2 gene results in unreceptive endometrium in women with idiopathic recurrent spontaneous miscarriage

Objective To investigate the expression pattern of proinflammatory, anti-inflammatory, and angiogenic cytokines and their effect on various mediators of endometrial receptivity in women with idiopathic recurrent spontaneous miscarriage (IRSM). Design A prospective study. Setting Tertiary care hospit...

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Veröffentlicht in:	Fertility and sterility 2013, Vol.99 (1), p.179-187.e2
Hauptverfasser:	Banerjee, Priyanka, M.Sc, Jana, Saikat Kumar, M.Sc, Pasricha, Pallavi, M.B.B.S, Ghosh, Sanghamitra, M.B.B.S, Chakravarty, Baidyanath, M.D, Chaudhury, Koel, Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion, Habitual - metabolism Abortion, Habitual - pathology Abortion, Habitual - physiopathology Adult Antigens, Surface - metabolism Biopsy Cadherins - metabolism Case-Control Studies Cyclooxygenase 2 - metabolism Cyclooxygenase-2 cytokines Cytokines - metabolism endometrial receptivity Endometrium - blood supply Endometrium - metabolism Endometrium - pathology Female Humans Integrin alphaVbeta3 - metabolism Internal Medicine Leukemia Inhibitory Factor - metabolism Matrix Metalloproteinase 9 - metabolism Membrane Proteins - metabolism MMP Mucin-1 - metabolism Neovascularization, Physiologic - physiology Obstetrics and Gynecology Pregnancy Prospective Studies Vascular Endothelial Growth Factor A - metabolism VEGF
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Beschreibung
Zusammenfassung:	Objective To investigate the expression pattern of proinflammatory, anti-inflammatory, and angiogenic cytokines and their effect on various mediators of endometrial receptivity in women with idiopathic recurrent spontaneous miscarriage (IRSM). Design A prospective study. Setting Tertiary care hospital and reproductive health research unit. Patient(s) Thirty-six women with IRSM (
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2012.08.034