Accumulation of inactive p53 protein in oral squamous cell carcinoma: stabilization by protein interaction

Accumulation of inactive p53 protein in oral squamous cell carcinoma: stabilization by protein interaction

Our previous study showed that p53 protein is accumulated in >60% of cases of oral squamous cell carcinoma (OSCC) and its overexpression is related to poor prognosis. However, the mechanism behind this is still elusive. The present study attempts to dissect p53 alterations at various levels from...

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Veröffentlicht in:European journal of oral sciences 2013-02, Vol.121 (1), p.21-28
Hauptverfasser: Francis, Geo, Dileep Kumar, U, Nalinakumari, KR, Jayasree, K, Kannan, S
Format: Artikel
Sprache:eng
Schlagworte:
accumulation
Adult
Aged
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
Cohort Studies
Dentistry
Female
Gene Expression Profiling - methods
Gene Expression Regulation, Neoplastic
Genes, p53
Humans
Male
Middle Aged
Mouth Neoplasms - genetics
Mouth Neoplasms - metabolism
Mutation
Oncogene Protein p21(ras) - genetics
Oncogene Protein p21(ras) - metabolism
oral cancer
overexpression
p53
p53, accumulation
Papillomavirus Infections - genetics
Papillomavirus Infections - metabolism
Polymorphism, Single Nucleotide
sequencing
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
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Beschreibung
Zusammenfassung:Our previous study showed that p53 protein is accumulated in >60% of cases of oral squamous cell carcinoma (OSCC) and its overexpression is related to poor prognosis. However, the mechanism behind this is still elusive. The present study attempts to dissect p53 alterations at various levels from gene to function in tumor biopsies to understand whether molecular alterations have any relationship with the accumulation of p53 protein in OSCC. Protein‐stabilizing mutations were observed in only 13.8% of the samples. Neither p53 polymorphisms nor human papillomavirus (HPV) infection (
ISSN:0909-8836
1600-0722
DOI:10.1111/eos.12007