Snail promotes Cyr61 secretion to prime collective cell migration and form invasive tumor nests in squamous cell carcinoma

Highlights ► We propose a invasion model of Oral squamous cell carcinomas that consists of EMT-dependent and Cyr61-dependent invasion. ► EMT phenotype cells lead the invasion and prime collective cell migration of other tumor cells with Cyr61 production. ► Humoral Cyr61 invokes the self-production o...

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Veröffentlicht in:	Cancer letters 2013-02, Vol.329 (2), p.243-252
Hauptverfasser:	Tanaka, Fumi, Rizqiawan, Andra, Higashikawa, Koichiro, Tobiume, Kei, Okui, Gaku, Shigeishi, Hideo, Ono, Shigehiro, Shimasue, Hiroshi, Kamata, Nobuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cancer Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell adhesion & migration Cell Line, Tumor Cell Movement Cyr61 Cysteine-Rich Protein 61 - metabolism EMT Epithelial-Mesenchymal Transition Extracellular matrix Feedback Feedback, Physiological Gene Expression Gene Expression Regulation, Neoplastic genes Genes, Reporter Hematology, Oncology and Palliative Medicine Humans Integrins - metabolism Luciferases, Renilla - biosynthesis Luciferases, Renilla - genetics Medical prognosis Metastasis Motility Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Neoplasm Invasiveness nests Promoter Regions, Genetic Proteins secretion Signal Transduction Snail Snail Family Transcription Factors Squamous cell carcinoma Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Tumor invasion
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Beschreibung
Zusammenfassung:	Highlights ► We propose a invasion model of Oral squamous cell carcinomas that consists of EMT-dependent and Cyr61-dependent invasion. ► EMT phenotype cells lead the invasion and prime collective cell migration of other tumor cells with Cyr61 production. ► Humoral Cyr61 invokes the self-production of Cyr61 in the tumor cells, resulting in a formation of tumor nests.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2012.11.023