Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A
Highlights ► The causes of tau phosphorylation in tauopathies such as Alzheimer's disease are still uncovered. ► Tau phosphorylation could be to the origin of Alzheimer's disease. ► Tau phosphatase dysfunctions might contribute to tau phosphorylation. ► Knowledge of the regulation modes of...
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| Veröffentlicht in: | Ageing research reviews 2013-01, Vol.12 (1), p.39-49 |
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| container_title | Ageing research reviews |
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| creator | Martin, Ludovic Latypova, Xenia Wilson, Cornelia M Magnaudeix, Amandine Perrin, Marie-Laure Terro, Faraj |
| description | Highlights ► The causes of tau phosphorylation in tauopathies such as Alzheimer's disease are still uncovered. ► Tau phosphorylation could be to the origin of Alzheimer's disease. ► Tau phosphatase dysfunctions might contribute to tau phosphorylation. ► Knowledge of the regulation modes of tau phosphatases allows to elaborate protection strategies. ► The most common compounds acting on each tau phosphatase are described. |
| doi_str_mv | 10.1016/j.arr.2012.06.008 |
| format | Article |
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| ispartof | Ageing research reviews, 2013-01, Vol.12 (1), p.39-49 |
| issn | 1568-1637 1872-9649 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alzheimer Disease - enzymology Alzheimer Disease - metabolism Animals Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Humans Internal Medicine Neurology Phosphoric Monoester Hydrolases - metabolism Protein Kinases - metabolism Protein Phosphatase 2 - antagonists & inhibitors Protein Phosphatase 2 - metabolism Protein Phosphatase 2 - physiology tau Proteins - metabolism |
| title | Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A |
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