Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

Highlights ► The causes of tau phosphorylation in tauopathies such as Alzheimer's disease are still uncovered. ► Tau phosphorylation could be to the origin of Alzheimer's disease. ► Tau phosphatase dysfunctions might contribute to tau phosphorylation. ► Knowledge of the regulation modes of...

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Veröffentlicht in:	Ageing research reviews 2013-01, Vol.12 (1), p.39-49
Hauptverfasser:	Martin, Ludovic, Latypova, Xenia, Wilson, Cornelia M, Magnaudeix, Amandine, Perrin, Marie-Laure, Terro, Faraj
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - enzymology Alzheimer Disease - metabolism Animals Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Humans Internal Medicine Neurology Phosphoric Monoester Hydrolases - metabolism Protein Kinases - metabolism Protein Phosphatase 2 - antagonists & inhibitors Protein Phosphatase 2 - metabolism Protein Phosphatase 2 - physiology tau Proteins - metabolism
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Beschreibung
Zusammenfassung:	Highlights ► The causes of tau phosphorylation in tauopathies such as Alzheimer's disease are still uncovered. ► Tau phosphorylation could be to the origin of Alzheimer's disease. ► Tau phosphatase dysfunctions might contribute to tau phosphorylation. ► Knowledge of the regulation modes of tau phosphatases allows to elaborate protection strategies. ► The most common compounds acting on each tau phosphatase are described.
ISSN:	1568-1637 1872-9649
DOI:	10.1016/j.arr.2012.06.008