Expression of Antiangiogenic Factors in the Placental Structures in Pre-Eclampsia

Expression of Antiangiogenic Factors in the Placental Structures in Pre-Eclampsia

Comparative morphological study of the placentas was carried out in women with pregnancy aggravated by the development of pre-eclampsia. Immunohistochemical methods showed increased expression of endoglin (CD105) and VEGFR1 in all placental structures. The intensity of endoglin and VEGFR1 expression...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2012-12, Vol.154 (2), p.287-291
Hauptverfasser: Shchyogolev, A. I., Dubova, E. A., Pavlova, K. A., Lyapin, V. M., Sukhikh, G. T.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Antigens, CD - metabolism
Antimitotic agents
Antineoplastic agents
Biomedical and Life Sciences
Biomedicine
Cell Biology
Endoglin
Female
Humans
Internal Medicine
Laboratory Medicine
Pathology
Placenta - metabolism
Pre-Eclampsia - metabolism
Preeclampsia
Pregnancy
Receptors, Cell Surface - metabolism
Trophoblasts - metabolism
Vascular endothelial growth factor
Vascular Endothelial Growth Factor Receptor-1 - metabolism
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Zusammenfassung:Comparative morphological study of the placentas was carried out in women with pregnancy aggravated by the development of pre-eclampsia. Immunohistochemical methods showed increased expression of endoglin (CD105) and VEGFR1 in all placental structures. The intensity of endoglin and VEGFR1 expression was maximum in the syncytiotrophoblast and extravillous cytotrophoblast cells in severe pre-eclampsia.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1932-0