Palladium-Catalyzed ortho-CH-Bond Oxygenation of Aromatic Ketones

Palladium-Catalyzed ortho-CH-Bond Oxygenation of Aromatic Ketones

A palladium-catalyzed C(sp2)–H bond oxygenation reaction is described. This protocol represents the first example of a C–H bond cleavage/C–O bond formation sequence, by employing a ketone moiety as the directing group. With this new catalytic method, a variety of ortho-acylphenols can be easily acce...

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Veröffentlicht in:Organic letters 2013-01, Vol.15 (2), p.270-273
Hauptverfasser: Choy, Pui Ying, Kwong, Fuk Yee
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Combinatorial Chemistry Techniques
Ketones - chemistry
Molecular Structure
Oxidation-Reduction
Palladium - chemistry
Phenols - chemical synthesis
Phenols - chemistry
Stereoisomerism
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Zusammenfassung:A palladium-catalyzed C(sp2)–H bond oxygenation reaction is described. This protocol represents the first example of a C–H bond cleavage/C–O bond formation sequence, by employing a ketone moiety as the directing group. With this new catalytic method, a variety of ortho-acylphenols can be easily accessed from arylketones.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol303088z