Evaluation of Natural Regulatory T Cells in Subjects with Selective IgA Deficiency: From Senior Idea to Novel Opportunities

Background: Selective IgA deficiency (SIgAD) is the most common primary immunodeficiency disorder, which is characterized by significantly decreased serum levels of IgA. Abnormalities of CD4+CD25 high forkhead box P3 (FoxP3)+ regulatory T cells (T reg ) have been shown in association with autoimmune...

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Veröffentlicht in:	International archives of allergy and immunology 2013-01, Vol.160 (2), p.208-214
Hauptverfasser:	Soheili, Habib, Abolhassani, Hassan, Arandi, Narges, Khazaei, Hossein Ali, Shahinpour, Shervin, Hirbod-Mobarakeh, Armin, Rezaei, Nima, Aghamohammadi, Asghar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Case-Control Studies Child Child, Preschool Female Flow Cytometry Humans IgA Deficiency - immunology IgA Deficiency - pathology Immune system Immunoglobulins Immunology Male Original Paper T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - pathology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology
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Zusammenfassung:	Background: Selective IgA deficiency (SIgAD) is the most common primary immunodeficiency disorder, which is characterized by significantly decreased serum levels of IgA. Abnormalities of CD4+CD25 high forkhead box P3 (FoxP3)+ regulatory T cells (T reg ) have been shown in association with autoimmune and inflammatory disorders. Methods: In order to evaluate the relationship between autoimmunity and T reg in SIgAD, we studied 26 IgA-deficient patients (aged 4–17 years) with serum IgA levels
ISSN:	1018-2438 1423-0097
DOI:	10.1159/000339867