Twin Pregnancy and Childbirth after Reduced-intensity Conditioning Allogeneic Haematopoietic Stem Cell Transplantation Combined with Imatinib Mesylate for Chronic Myeloid Leukaemia: Case Report and Literature Review

The successful outcome of a pregnancy in a woman who had received reduced-intensity conditioning (RIC) allogeneic haematopoietic stem cell transplantation (allo-HSCT) for chronic myeloid leukaemia is reported; publications on recovery of ovarian function and pregnancy following myeloablative conditi...

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Veröffentlicht in:Journal of international medical research 2012-12, Vol.40 (6), p.2409-2415
Hauptverfasser: Wua, K-N, Luoa, Y, Liu, L-Z, Zhao, Y-M, Hu, Y-X, Tan, Y-M, Lai, X-Y, Huang, H
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Sprache:eng
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Zusammenfassung:The successful outcome of a pregnancy in a woman who had received reduced-intensity conditioning (RIC) allogeneic haematopoietic stem cell transplantation (allo-HSCT) for chronic myeloid leukaemia is reported; publications on recovery of ovarian function and pregnancy following myeloablative conditioning (MAC) or RIC allo-HSCT for haematological disorders are reviewed. Research suggests that RIC allo-HSCT may facilitate ovarian recovery. Indeed, in the case study presented, the patient had a successful twin pregnancy and delivery, subsequent to treatment. After a 5-year follow-up, the patient survives disease-free with a sustained molecular response; her children are both healthy, with no physical defects. These findings suggest that RIC allo-HSCT combined with short-term imatinib mesylate does not necessarily have profound effects on female fertility.
ISSN:0300-0605
1473-2300
DOI:10.1177/030006051204000640