Axial distribution of nitric oxide airway production in asthma patients

Highlights ► Challenges-induced exhaled NO decreases reflect production in the involved areas. ► Distal and proximal sites are both involved in NO overproduction in asthma. ► In asthma patients, NO overproduction involves the most part of the airways.

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Bibliographische Detailangaben
Veröffentlicht in:	Respiratory physiology & neurobiology 2013-01, Vol.185 (2), p.313-318
Hauptverfasser:	Van Muylem, Alain, Kerckx, Yannick, Michils, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Monophosphate Adrenal Cortex Hormones - metabolism Adult AMP challenge Asthma Asthma - metabolism Asthma - pathology Asthma - physiopathology Breath Tests Bronchi - drug effects Bronchi - metabolism Bronchoconstriction - drug effects Cross-Over Studies Exhaled nitric oxide Female Forced Expiratory Volume Humans Male Medical Education Methacholine challenge Methacholine Chloride Middle Aged Muscarinic Agonists Nitric Oxide - metabolism Pulmonary Ventilation - drug effects Pulmonary Ventilation - physiology Pulmonary/Respiratory Single-Blind Method Vital Capacity - drug effects
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Beschreibung
Zusammenfassung:	Highlights ► Challenges-induced exhaled NO decreases reflect production in the involved areas. ► Distal and proximal sites are both involved in NO overproduction in asthma. ► In asthma patients, NO overproduction involves the most part of the airways.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2012.09.011