Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression

Highlights ► Depressive and anxiety-like behaviours elicited by poly I:C are associated with a reduction in BDNF signalling, and activation of the kynurenine pathway, but not a reduction in serotonin.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2013-02, Vol.28, p.170-181
Hauptverfasser:	Gibney, Sinead M, McGuinness, Barry, Prendergast, Christine, Harkin, Andrew, Connor, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Anxiety - chemically induced Anxiety - immunology BDNF Brain-Derived Neurotrophic Factor - antagonists & inhibitors Brain-Derived Neurotrophic Factor - physiology CD11b Antigen - physiology Cytokine Depression Depression - chemically induced Depression - immunology Frontal Lobe - metabolism Hippocampus - metabolism IDO IL-1 IL-6 Illness Behavior - physiology Inflammation Interleukin-1beta - physiology Interleukin-6 - physiology Kynurenine Kynurenine - physiology Male Poly I-C - pharmacology Poly I:C Psychiatry Rats Rats, Sprague-Dawley Serotonin Signal Transduction - drug effects Signal Transduction - physiology TNF-α Tumor Necrosis Factor-alpha - physiology
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Beschreibung
Zusammenfassung:	Highlights ► Depressive and anxiety-like behaviours elicited by poly I:C are associated with a reduction in BDNF signalling, and activation of the kynurenine pathway, but not a reduction in serotonin.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2012.11.010